To evaluate the performance of the BinaxNOW rapid antigen test, it was used along with real-time reverse transcription–polymerase chain reaction (RT-PCR) testing to analyze 3,419 paired specimens collected from persons aged ≥10 years at two community testing sites in Pima County, Arizona, during November 3–17, 2020.
Rapid antigen tests have received Food and Drug Administration (FDA) Emergency Use Authorization (EUA) for use in symptomatic persons ( 2), but data are lacking on test performance in asymptomatic persons to inform expanded screening testing to rapidly identify and isolate infected persons ( 3). Rapid antigen tests, such as the Abbott BinaxNOW COVID-19 Ag Card (BinaxNOW), offer results more rapidly (approximately 15–30 minutes) and at a lower cost than do highly sensitive nucleic acid amplification tests (NAATs) ( 1). Antigen tests can be an important tool in an overall community testing strategy to reduce transmission. The high specificity and rapid BinaxNOW antigen test turnaround time facilitate earlier isolation of infectious persons. What are the implications for public health practice? Sensitivity was higher for culture-positive specimens (92.6% and 78.6% for those from symptomatic and asymptomatic persons, respectively) however, some antigen test-negative specimens had culturable virus. Sensitivity of the BinaxNOW antigen test, compared with polymerase chain reaction testing, was lower when used to test specimens from asymptomatic (35.8%) than from symptomatic (64.2%) persons, but specificity was high. The BinaxNOW rapid antigen test received Emergency Use Authorization by the Food and Drug Administration for testing specimens from symptomatic persons performance among asymptomatic persons is not well characterized. Bower, MD 1 ( View author affiliations) View suggested citation Neatherlin, MPH 1 Mark Anderson, MD 1 Paul A. Kirking, MD 1 Khalilullah Sheiban, MD 4 Julie Kudrna, MPA 4 Theresa Cullen, MD 4 Kenneth K. Folster, PhD 1 Adam MacNeil, PhD 1 Reynolds Salerno, PhD 1 Wendi Kuhnert-Tallman, PhD 1 Jacqueline E. Shewmaker, PhD 1 Magdalena Medrzycki, PhD 1 Phili Wong, MS 1 Shilpi Jain, PhD 1 Alexandra Tejada-Strop, MS 1 Shannon Rogers, MS 1 Brian Emery 1 Houping Wang, PhD 1 Marla Petway, MPH 1 Caitlin Bohannon, PhD 1 Jennifer M. Bui, PhD 1 ,3 Tracy Powell, PhD 1 Azaibi Tamin, PhD 1 Jennifer L. Stevens 1 Kristen Knipe, MS 1 Justine Pompey, PhD 1 Christine Atherstone, PhD 1 ,3 David P. Buono, PhD 1 Molly Deutsch-Feldman, PhD 1 ,3 Suganthi Suppiah, PhD 1 LiJuan Hao, MD 1 Yan Zeng, MS 1 Valerie A. Prince-Guerra, PhD 1 Olivia Almendares, MSPH 1 Leisha D. Please note: This report has been corrected.
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